Saline Creek (Ste. Genevieve County)

Saline Creek is a large creek that drains a significant area of Ste. Genevieve County. It briefly flows into Perry County, but the majority of its course is in Ste. Genevieve County. It rises near the Saint Francois County line in the village of Avon and immediately flows east. On the edge of Mark Twain National Forest, it meets Coldwater Creek in the village of Clearwater. Its next major tributary is Madden Creek. Saline Creek then collects Johns Creek and Brushy Creek. Near the village of Minnith, Saline Creek receives the South Fork. It then crosses into Perry County under Interstate 55. Below 55, Little Saline Creek enters as Saline Creek meanders north. It enters the Old River north of Saint Marys.

Like the other creeks before it, Saline Creek is an independent stream, meaning it doesn't quite qualify for having its own basin, however the amount of tributaries feeding into it could qualify it as its own basin. The creek has been reported as floatable, however it is only floatable after periods of rain in its upper reaches. Saline Creek is typical of an Ozarks stream, its valley is narrow but steep sided. The water is crystal clear.